Common Mechanism for Detecting Multiple DDoS Attacks

An important principle of an internet-based system is information security. Information security is a very important aspect of distributed systems and IoT (Internet of Things) based wireless systems. The attack which is more harmful to the distributed system and IoT-based wireless system is a DDoS (Distributed Denial of Service) attack since in this attack, an attacker can stop the work of all other connected devices or users to the network. For securing distributed applications, various intrusion detection mechanisms are used. But most existing mechanisms are only concentrated on one kind of DDoS attack. This paper focuses on the basic architecture of IoT systems and an overview of single intrusion detection systems. This paper presents a single detection method for different DDoS attacks on distributed systems with an IoT interface. In the future, the system will provide support for detecting and preventing different DDoS attacks in IoT-based systems

Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen.

Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, renal, gastrointestinal and liver injuries. The underlying mechanisms of ibuprofen-mediated effects on liver remain unclear. To determine the mechanisms and signaling pathways affected by ibuprofen (100 mg/kg/day for seven days), we performed proteomic profiling of male mice liver with quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) using ten-plex tandem mass tag (TMT) labeling. More than 300 proteins were significantly altered between the control and ibuprofen-treated groups. The data suggests that several major pathways including (1) energy metabolism, (2) protein degradation, (3) fatty acid metabolism and (4) antioxidant system are altered in livers from ibuprofen treated mice. Independent validation of protein changes in energy metabolism and the antioxidant system was carried out by Western blotting and showed sex-related differences. Proteasome and immunoproteasome activity/expression assays showed ibuprofen induced gender-specific proteasome and immunoproteasome dysfunction in liver. The study observed multifactorial gender-specific ibuprofen-mediated effects on mice liver and suggests that males and females are affected differently by ibuprofen

Relações entre o perfil empreendedor e o desenvolvimento de competências socioemocionais

No abstract.As potenciais capacidades emocionais do indivíduo são adquiridas ao longo da vida, de acordo com sua experiência, por meio da introdução social, familiar e escolar através da educação e da prática profissional. O presente artigo tem o objetivo de analisar o perfil empreendedor dos empreendedores de João Pessoa - PB e o desenvolvimento de competências socioemocionais. O tema envolve a relevância das emoções do empreendedor e suas competências. Para que os empreendedores possam obter êxito na vida de uma forma geral, estudo, carreira e vida pessoal, se faz necessário uma série de competências e habilidades em diversas áreas. A estratégia de pesquisa adotada foi o Survey, utilizando-se de um questionário estruturado como instrumento de coleta de dados. A pesquisa foi realizada com um total de 76 empreendedores, entre 17 e 64 anos, na cidade de João Pessoa - PB, com adoção do método de pesquisa quantitativo, foi utilizado o SPSS para a análise estatística. Como principais resultados foi possível destacar que os empreendedores de João Pessoa são na sua maioria de alto grau de educação formal, jovens entre 17 a 31 anos. A pesquisa mostrou diferença de média relacionada ao gênero masculino e feminino em relação ao quesito Regulação Emocional, mostrou que os homens têm uma maior regulação emocional que as mulheres. A pesquisa também mostrou que os empreendedores admitem correr riscos em troca de possíveis benefícios, bem como também a importância dada aos contatos sociais voltados a vida profissional. Verificou-se ainda que estes empreendedores, em sua maioria criaram seus negócios por estarem desempregados, motivados pela necessidade e em busca de realização pessoal, para aproveitar uma oportunidade de mercado ou para alcançar a independência financeira. As empresas constituídas por eles são de pequeno porte, do setor de comércio e serviço em sua grande maioria. O estudo das competências socioemocionais possibilita o autoconhecimento, ensinando o indivíduo a controlar suas próprias emoções, respondendo bem a situações de estresse para com isso obter uma melhor qualidade de vida. Adaptação e evolução positiva perante a situações de mudanças, com facilidade em socializar-se e estar sempre aberto a novas forma de pensar, agindo de maneira responsável

Are heat shock proteins an important link between type 2 diabetes and Alzheimer disease?

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD. Here, we review the role of HSP in moderating T2D and AD, as well as propose that these chaperone proteins are an important link in the relationship between T2D and AD

O avanço conceitual do subcampo da Economia Política da Informação, da Comunicação e da Cultura a partir da Revista EPTIC

Resumo Este artigo faz parte de um projeto que busca mapear os estudos da Economia Política da Informação, da Comunicação e da Cultura (EPC) no Brasil, dando sequência a uma pesquisa que analisou de forma mais quantitativa e estrutural o período de 1999 a 2015 da Revista Eletrônica Internacional de Economia Política da Informação, da Comunicação e da Cultura (Revista EPTIC), o primeiro periódico científico a dedicar-se à divulgação e ao fomento de pesquisas em EPC na América Latina. Assim, o trabalho, a partir de uma amostra, analisará quais conceitos ligados a este eixo teórico-metodológico são apresentados neste período, levando em consideração os artigos que têm a EPC como palavra-chave; e, a partir disso, verificará quais autores são citados e se isso tem influência do objeto de estudo. Palavras-chave: Economia Política da Comunicação; Revista EPTIC Online; Epistemologia.   Resumen Este artículo es parte de un proyecto que busca un mapa de los estudios de Economía Política de la Información, Comunicación y Cultura (EPC) en Brasil, a raíz de una investigación que analizó de manera más cuantitativa y estructuralmente el período de 1999 a 2015 el Revista Eletrônica Internacional de Economia Política da Informação, da Comunicação e da Cultura (Revista EPTIC), la primera revista dedicó a la difusión y promoción de la investigación en EPC en América Latina. Así que el trabajo, a partir de una muestra, analizar cuales conceptos vinculados a este eje teórico-metodológico se muestra en este período, teniendo en cuenta los elementos que tienen el EPC como palabra clave; y, a partir de eso, comprobar que los autores se citan y si afecta el objeto de estudio. Palabras clave: Economía Política de la Comunicación; Revista EPTIC; Epistemología.   Abstract This article is part of a project that seeks to map the studies of Political Economy of Information, Communication and Culture (EPC) in Brazil, following on from research that analyzed more quantitatively and structurally the period 1999-2015 the Revista Eletrônica Internacional de Economia Política da Informação, da Comunicação e da Cultura (Revista EPTIC), the first journal dedicated himself to the dissemination and promotion of research in EPC in Latin America. So the work, from a sample, analyze what concepts linked to this theoretical-methodological axis is displayed in this period, taking into account the items that have the EPC as a keyword; and, from that, check which authors are cited and if it affects the object of study. Keywords: Political Economy of Communication; Revista EPTIC; Epistemology

Being open, feeling safe and getting creative: The role of team mean openness to experience in the emergence of team psychological safety and team creativity

Although the effects of openness to experience (OTE) on individual creativity are well-established, research on how such effects unfold in a team context is scarce. Drawing on theories of group norms and uncertainty reduction, we argue that team mean OTE leads to a climate of team psychological safety which, in turn, facilitates team creativity. We test our hypothesis over three independent studies, the first comprising 35 business student project teams, the second based on 28 professional teams from the automotive industry, both conducted in the United Kingdom, and the third comprising 24 healthcare teams in Portugal. As predicted, across all three studies, team mean OTE was positively associated with team creativity via the affective emergent state of team psychological safety. Furthermore, the mediating role of team psychological safety remained significant even when accounting for team OTE variance, alternative motivational and cognitive emergent states, namely team promotion focus (studies 1 and 2) and team exploration climate (study 3), as well as empowering leadership (study 3). Finally, in study 3, we examined the differential impact of the two major facets of OTE, intellect, and openness, and found that intellect, but not openness, was responsible for driving the indirect effects. Further analysis did not support alternative perspectives concerning team OTE variance or the interaction between mean and variance. Our findings not only contribute to theoretical understanding regarding the relationship between team personality composition, specifically OTE, and team creativity but also provide much-needed insight into how such effects unfold. We delineate several practical implications for team design and development

Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322

The authors wish to make the following corrections to this paper [1]: There are metadata errors in Supplementary Figure S2 and Table 8, which state that isolate 17BRD-035 was isolated from a feedlot in NSW when in fact it came from Queensland. Figure S2 in Supplementary Materials was changed accordingly and was included with a separate document: https://www.mdpi.com/article/10.3390/microorganisms9061322/s1 In Table 8, the ST column for strain P. m 17BRD-035 was changed from NSW to QLD, the correct Table 8 is as follows: Table 8. Resistance profile, RAPD pattern and presence of antimicrobial resistance genes among isolates of Pasteurella multocida (P. m) (n = 28) and Mannheimia haemolytica (M. h) (n = 1) +, present, −, absent. Table (see supplement) The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original article has been updated

Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment

Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities. The urine point-of-care circulating cathodic antigen test (POC-CCA) is potentially more sensitive but how accurately they detect S. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts remain to be fully understood. We compared the accuracies of one to six Kato-Katzs and one POC-CCA for the diagnosis of S. mansoni in primary-school children who have received zero to ten praziquantel treatments. We determined the impact each diagnostic approach may have on monitoring and evaluation (M&E) and drug-efficacy findings